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(1R,2R)-2-PCCA hydrochloride

Name: (1R,2R)-2-PCCA hydrochloride
Brand: TargetMol
SKU: T13423
Price: 98 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13423Cas No. 1609563-71-4

Alias (1R,2R)-2-PCCA(hydrochloride)

(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.

(1R,2R)-2-PCCA hydrochloride

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Purity: 99.67%

Catalog No. T13423Alias (1R,2R)-2-PCCA(hydrochloride)Cas No. 1609563-71-4

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$98	In Stock	In Stock
5 mg	$147	In Stock	In Stock
10 mg	$289	In Stock	In Stock
25 mg	$596	In Stock	In Stock
50 mg	$787	In Stock	In Stock
100 mg	$1,070	-	In Stock
1 mL x 10 mM (in DMSO)	$169	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.67%

ee:99.02%

Appearance:Solid

Color:Yellow

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COA CSFC HNMR IC LCMS ORP

Product Introduction

Bioactivity

Description	(1R,2R)-2-PCCA hydrochloride is a potent, selective, and blood-brain-barrier-crossing GPR88 receptor agonist with an EC50 value of 1140 n in striatal membranes of WT mice; it can be used to study the central nervous system.
Targets&IC50	GPR88-22F cells:603 nM (EC50), GPR88 receptor:3 nM (EC50, cell-free assay), GPR88 receptor:56 nM (EC50, HEK293 cell)
In vitro	(1R,2R)-2-PCCA hydrochloride (Example 3) is an effective GPR88 receptor agonist with an EC50 of 3 nM in cell-free assay experiments and 603 nM in cellular assays[1]. Through the Gαi-coupled pathway, (1R,2R)-2-PCCA hydrochloride inhibits GPR88-mediated cAMP production, with an EC50 of 56 nM cAMP constructs in HEK293 cells stably expressing human GPR88 receptor and GloSensor-22F[1].
Synonyms	(1R,2R)-2-PCCA(hydrochloride)

Chemical Properties

Molecular Weight	528.56
Formula	C₃₀H₃₉Cl₂N₃O
Cas No.	1609563-71-4
Smiles	Cl.Cl.CCCc1ccc(cc1)-c1ccc(cc1)N(C[C@@H](N)[C@@H](C)CC)C(=O)[C@@H]1C[C@H]1c1ccccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 20 mg/mL (37.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8919 mL	9.4597 mL	18.9193 mL	94.5966 mL
5 mM	0.3784 mL	1.8919 mL	3.7839 mL	18.9193 mL
10 mM	0.1892 mL	0.9460 mL	1.8919 mL	9.4597 mL
20 mM	0.0946 mL	0.4730 mL	0.9460 mL	4.7298 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc